General Information

  • ID:  hor000289
  • Uniprot ID:  NA
  • Protein name:  Amolopkinins W1
  • Gene name:  NA
  • Organism:  Chinese torrent frog
  • Family:  Bradykinin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  RVALPPGFTPFR
  • Length:  12
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Antagonize the contractile effects of canonical bradykinin on ileum smooth muscle
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000289_AF2.pdbhor000289_ESM.pdb

Physical Information

Mass: 155399 Formula: C65H100N18O14
Absent amino acids: CDEHIKMNQSWY Common amino acids: P
pI: 12.5 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 5
Hydrophobicity: 4.17 Boman Index: -1474
Half-Life: 1 hour Half-Life Yeast: 2 min
Half-Life E.Coli: 2 min Aliphatic Index 65
Instability Index: 5731.67 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  19428766
  • Title:  Amolopkinins W1 and W2--novel Bradykinin-Related Peptides (BRPs) From the Skin of the Chinese Torrent Frog, Amolops Wuyiensis: Antagonists of Bradykinin-Induced Smooth Muscle Contraction of the Rat Ileum